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Ro 48-8071

CAS No. 161582-11-2

Ro 48-8071 ( Ro-488071 )

Catalog No. M12352 CAS No. 161582-11-2

A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ro 48-8071
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.
  • Description
    A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical
  • Synonyms
    Ro-488071
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Dyslipidemia

Chemical Information

  • CAS Number
    161582-11-2
  • Formula Weight
    448.37
  • Molecular Formula
    C23H27BrFNO2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CN(CCCCCCOC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F)CC=C
  • Chemical Name
    Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Morand OH, et al. J Lipid Res. 1997 Feb;38(2):373-90.
2. Peffley DM, et al. Biochem Pharmacol. 1998 Aug 15;56(4):439-49.
3. Liang Y, et al. Onco Targets Ther. 2016 May 30;9:3223-32.
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