Ro 48-8071

Research use only, not for human use.

A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM.

A potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM; 6 times less potent against hamster and Gottingen minipig liver OSC, and 10-times more potent against squirrel monkey liver OSC; blocks human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; triggers the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol.Dyslipidemia Preclinical

Ro-488071

Others

Other Targets

Other Targets

Cardiovascular Disease

Dyslipidemia

161582-11-2

448.37

C23H27BrFNO2

>98% (HPLC)

10 mM in DMSO

CN(CCCCCCOC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F)CC=C

Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]-

(-20℃)

With Ice Pack

≥ 2 years